Welcome Cassie Nelson to the OS Lab!

Dr. Cassandra (Cassie) Nelson began working as a postdoctoral researcher in the OS Lab in October. Cassie completed her doctoral training in the Biological Sciences Department at the University of Maryland, Baltimore County in the fall of 2017. Using a combination of transcriptomics, microbial genetics and physiology, her dissertation work determined the physiological roles of the glycoside hydrolase family 3 enzymes in the bacterium Cellvibrio japonicus. She is currently studying how iron regulation affects the physiology and interactions between Pseudomonas aeruginosa and Staphylococcus aureus. Welcome Cassie to the OS Lab!!

Postdoctoral Positions in the OS Lab

POSTDOCTORAL POSITIONS IN BACTERIAL PATHOGENESIS AND GENETICS

The University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences (PSC), invites applications for a postdoctoral position to work with Amanda Oglesby-Sherrouse, Ph.D, on a project funded by the National Institutes of Health. The successful candidate will conduct studies on a) the mechanisms of iron and heme regulation by the PrrF and PrrH small regulatory RNAs (sRNAs) of Pseudomonas aeruginosa, and b) the impact of these sRNAs on iron homeostasis and acute lung infection. These studies will involve the application of bacterial genetics, transcriptomics, biochemical/biophysical analysis of sRNA regulation, and mass spectrometry-based metabolite analysis. The successful candidate will be expected to participate in vibrant collaborations with investigators at Johns Hopkins University, West Virginia University, and the School of Pharmacy’s Mass Spectrometry Center. Candidates will benefit from the highly collaborative and interdisciplinary research community of the PSC Department and broader UM Baltimore research community.

Applicants should apply directly to Dr. Oglesby-Sherrouse (aoglesby@rx.umaryland.edu) and send a cover letter, CV, and contact information for three references.

Qualifications

The qualified applicant will have a Ph.D. in microbiology, molecular biology, or related field. Applicants should be highly motivated and possess excellent oral and written communication skills. Applicants should also have the ability to work both independently as well as part of a collaborative research group. Preference will be given to applicants with demonstrated experience in microbial pathogenesis, gene expression studies, sRNA biology or biochemistry, and bacterial genetics.

Equal Opportunity/Affirmative Action Employer. Minorities, women, protected veterans, and individuals with disabilities are encouraged to apply.

UMB Commencement 2018

The OS Lab marked another milestone last week at the UMB Commencement Ceremonies. Dr. Oglesby-Sherrouse had the privilege of “hooding” her second doctoral student, Dr. Angie Nguyen. Dr. Nguyen is currently pursing postdoctoral studies as an ORISE fellow at the FDA. Congratulations Dr. Nguyen!!!

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OS Lab research featured by Journal of Bacteriology

Angie Nguyen’s most recent study, demonstrating how iron impacts P. aeruginosa’s  interactions with Staphylococcus aureus, was just accepted for publication by Journal of Bacteriology. P. aeruginosa and S. aureus both commonly infect the lungs of cystic fibrosis (CF) patients. Less appreciated is the knowledge that S. aureus is much more commonly identified in young CF patients, while P. aeruginosa eventually takes its place. P. aeruginosa produces numerous antimicrobial factors that likely contribute to this shift in microbial populations. How these systems drive changes in the microbial make-up of the CF lung remain poorly understood. Angie’s work demonstrates that iron depletion enhances antimicrobial activity of P. aeruginosa towards S. aureus, indicating iron availability may play a critical role in modulating the microbial make-up of the CF lung. Angie’s study, as well as a separate report on P. aeruginosa interactions with S. aureus, are being featured by the Journal of Bacteriology with an accompanying commentary. Congratulations to Angie and our collaborators on being recognized for their awesome work!!

OS Lab members recognized at the UMB Graduate Research Conference

The UMB Graduate Research Conference took place yesterday at the UMB student center. OS lab members Angie Nguyen, Alexandria Reinhart, and Louise Djapgne all participated either through oral or poster presentations.

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Left to right: Alexandria Reinhart, Mandy Oglesby-Sherrouse, Angie Nguyen

At the end of the day OS lab members Angie Nguyen and Alexandria Reinhart both received Outstanding Oral Presentation awards. Alexandria’s abstract was entitled “Regulation of the PrrF and PrrH small RNAs in Pseudomonas aeruginosa“. Angie’s abstract was entitled “Iron depletion enhances antimicrobial activity of Pseudomonas aeruginosa against Staphylococcus aureus.”

Louise Djapgne presented a poster on her work entitled “Characterizing interactions between Hfq and the PrrF and PrrH small RNAs of Pseudomonas aeruginosa“. Louise and Angie were also both recognized during the UMB PhD candidacy ceremony for successful completion of their qualifying examinations this past fall.