OS Lab News

UMB Commencement 2017

The OS Lab marked another milestone last week at the UMB Commencement Ceremonies. Dr. Oglesby-Sherrouse had the privilege of “hooding” her second doctoral student, Dr. Angie Nguyen. Dr. Nguyen is currently pursing postdoctoral studies as an ORISE fellow at the FDA. Congratulations Dr. Nguyen!!!

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OS Lab research featured by Journal of Bacteriology

Angie Nguyen’s most recent study, demonstrating how iron impacts P. aeruginosa’s  interactions with Staphylococcus aureus, was just accepted for publication by Journal of Bacteriology. P. aeruginosa and S. aureus both commonly infect the lungs of cystic fibrosis (CF) patients. Less appreciated is the knowledge that S. aureus is much more commonly identified in young CF patients, while P. aeruginosa eventually takes its place. P. aeruginosa produces numerous antimicrobial factors that likely contribute to this shift in microbial populations. How these systems drive changes in the microbial make-up of the CF lung remain poorly understood. Angie’s work demonstrates that iron depletion enhances antimicrobial activity of P. aeruginosa towards S. aureus, indicating iron availability may play a critical role in modulating the microbial make-up of the CF lung. Angie’s study, as well as a separate report on P. aeruginosa interactions with S. aureus, are being featured by the Journal of Bacteriology with an accompanying commentary. Congratulations to Angie and our collaborators on being recognized for their awesome work!!

OS Lab members recognized at the UMB Graduate Research Conference

The UMB Graduate Research Conference took place yesterday at the UMB student center. OS lab members Angie Nguyen, Alexandria Reinhart, and Louise Djapgne all participated either through oral or poster presentations.

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Left to right: Alexandria Reinhart, Mandy Oglesby-Sherrouse, Angie Nguyen

At the end of the day OS lab members Angie Nguyen and Alexandria Reinhart both received Outstanding Oral Presentation awards. Alexandria’s abstract was entitled “Regulation of the PrrF and PrrH small RNAs in Pseudomonas aeruginosa“. Angie’s abstract was entitled “Iron depletion enhances antimicrobial activity of Pseudomonas aeruginosa against Staphylococcus aureus.”

Louise Djapgne presented a poster on her work entitled “Characterizing interactions between Hfq and the PrrF and PrrH small RNAs of Pseudomonas aeruginosa“. Louise and Angie were also both recognized during the UMB PhD candidacy ceremony for successful completion of their qualifying examinations this past fall.

Congratulations to Alexandria on her first lead author paper!!

Alexandria’s work on PrrF and PrrH regulation in Pseudomonas aeruginosa was just accepted for publication by Infection and Immunity! This study establishes the role of the prrF-encoded sRNAs in iron homeostasis and virulence, in particular demonstrating that the prrF locus is required for acute murine lung infection. Congratulations to Alexandria, as well as all of our collaborators who contributed to this study!!

Louise Djapgne named a Meyerhoff Graduate Fellow

Louise Djapgne, a third-year PSC graduate student in the OS Lab, has been named a Meyerhoff Graduate Fellow! The Meyerhoff Fellows Graduate Program provides financial assistance and networking opportunities to PhD students from underrepresented groups, with the goal of “promoting cultural diversity in the biomedical sciences”. A full story is available on the School of Pharmacy website. Congratulations Louise!